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Structural Biology
In nature, structure defines function. We elucidate the molecular architecture of proteins and macromolecular complexes to understand these fascinating nanomachines’ molecular mechanisms, which are involved in all cellular functions. In the Department of Structural Biology at the University of Osnabrück, we are mainly concerned with membrane proteins. We analyze their structural dynamics to understand how they function; for this purpose, we use cryo-EM.
Research Topics
- Dynamics of membrane proteins
- Structrue determination of multimeric proteincomplexes
- Synergies between lipids and proteins
- Method development in cryo-EM
Model Systems
- Various membrane proteins
- Reconstituted membrane systems
- Isolated proteins and protein complexes
Methods
- Cryo-EM
- Single particel analysis
- Tomography
- Protein expression and purification
- Programming in python
Selected Publications
Hofmann S, Januliene D, Mehdipour AR, Thomas C, Stefan E, Brüchert S, Kuhn BT, Geertsma ER, Hummer G, Tampé R, &Moeller A (2019). Conformation space of a heterodimeric ABC exporter under turnover conditions. Nature 571, 580–583. doi: 10.1038/s41586-019-1391-0 pdf
Timcenko M, Lyons JA, Januliene D, Ulstrup JJ, Dieudonné T, Montigny C, Ash M, Karlsen JL, Boesen T, Kühlbrandt W, Lenoir G*, Moeller A*, & Nissen P* (2019). Structure and autoregulation of a P4-ATPase lipid flippase. Nature 571, 366–370. doi: 10.1038/s41586-019-1344-7 pdf
Blees A, Januliene D, Hofmann T, Kolle, N, Schmidt C, Trowitzsch S*, Moeller A*, & Tampé R*. (2017). Structure of the human MHC-I peptide-loading complex. Nature 551, 525–528. doi: 10.1038/nature24627 pdf
More information
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